Compile Data Set for Download or QSAR
Found 125 from Piramal Life Sciences
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50214095(CHEMBL248713 | CHEMBL511394 | N-((5-(3-(5-fluoro-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of CDK1/cyclinB (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GKBPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50262025(3-(6-(2,4-difluorophenylamino)-1H-pyrazolo[3,4-b]p...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GKBPubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354637(CHEMBL1834440)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354642(CHEMBL1834204)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354639(CHEMBL1834201)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354638(CHEMBL1834200)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM20716((1R,2R)-2-[(4-{4-[(phenylcarbamoyl)amino]phenyl}ph...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human DGAT1 expressed in Sf9 cells assessed as formation of didecanoylglycerol product after 1 hr using 14C-decanoyl-CoA by beta scinti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM20716((1R,2R)-2-[(4-{4-[(phenylcarbamoyl)amino]phenyl}ph...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354641(CHEMBL1834203)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354631(CHEMBL1834433)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354629(CHEMBL1834431)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354634(CHEMBL1834436)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354633(CHEMBL1834435)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354636(CHEMBL1834438)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354640(CHEMBL1834202)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354630(CHEMBL1834432)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354643(CHEMBL1834206)copy SMILEScopy InChI
Affinity DataIC50: 73nMAssay Description:Inhibition of human DGAT1 expressed in Sf9 cells assessed as formation of didecanoylglycerol product after 1 hr using 14C-decanoyl-CoA by beta scinti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354632(CHEMBL1834434)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetDiacylglycerol O-acyltransferase 1(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM50354635(CHEMBL1834437)copy SMILEScopy InChI
Affinity DataIC50: 99nMAssay Description:Inhibition of human DGAT1 assessed as formation of [14C]-triglyceride using [14C]oleoyl-CoA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8M29PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Piramal Life Sciences Limited

Curated by ChEMBL
LigandPNGBDBM5768((4-butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(phenyl)m...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2GKBPubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50298023(2-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of dopachrome tautomerase activity of MIF in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0387WPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329895(2-chloro-N-(6-(4-hydroxy-6-(trifluoromethyl)pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50298023(2-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of dopachrome tautomerase activity of human recombinant MIFMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0387WPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329898(2-chloro-N-(6-(4-chloro-6-(trifluoromethyl)pyrimid...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50298023(2-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0387WPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329891(2-chloro-N-(6-(5-ethyl-4-hydroxy-6-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329892(2-chloro-N-(6-(4-(chloromethyl)-6-hydroxypyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329896(CHEMBL1271980 | N-(6-(4-(allyloxy)-5-chloro-6-meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329899(CHEMBL1271924 | N-(6-(4-(allyloxy)-5-ethyl-6-methy...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329894(2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50298024(2-(3-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of dopachrome tautomerase activity of MIF in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0387WPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329887(CHEMBL1271978 | N-(6-(4-(allyloxy)-6-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50008935((20S)-10-Dimethylaminomethyl-4-ethyl-4,9-dihydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329888(2-chloro-N-(6-(4-methoxy-6-(trifluoromethyl)pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329889(CHEMBL1271868 | N-(6-(5-benzyl-4-hydroxy-6-methylp...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329892(2-chloro-N-(6-(4-(chloromethyl)-6-hydroxypyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329891(2-chloro-N-(6-(5-ethyl-4-hydroxy-6-methylpyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329890(2-chloro-N-(6-(5-chloro-4-hydroxy-6-methylpyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329894(2-chloro-N-(6-(5-fluoro-4-hydroxy-6-methylpyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329893(2-(5-aminopyridin-2-yl)-6-(chloromethyl)pyrimidin-...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50298024(2-(3-(3-(3-fluoro-4-hydroxyphenyl)-4,5-dihydroisox...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of dopachrome tautomerase activity of human recombinant MIFMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0387WPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329895(2-chloro-N-(6-(4-hydroxy-6-(trifluoromethyl)pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329897(2-chloro-N-(6-(4-ethoxy-6-(trifluoromethyl)pyrimid...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under hypoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329896(CHEMBL1271980 | N-(6-(4-(allyloxy)-5-chloro-6-meth...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50298009(CHEMBL559125 | N-cyclohexyl-3(3-(3-(3-fluoro-4-met...)copy SMILEScopy InChI
Affinity DataIC50: 9.50E+3nMAssay Description:Inhibition of dopachrome tautomerase activity of human recombinant MIFMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0387WPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329898(2-chloro-N-(6-(4-chloro-6-(trifluoromethyl)pyrimid...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50298021(4-fluoro-N-(2-(3-(3-fluoro-4-hydroxyphenyl)-4,5-di...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of spontaneous secretion/release/recognition of MIF from freshly isolated human PBMC by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0387WPubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50329889(CHEMBL1271868 | N-(6-(5-benzyl-4-hydroxy-6-methylp...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HIF1alpha in human U251 cells under normoxic condition by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HX1CXMPubMed
TargetMacrophage migration inhibitory factor(Homo sapiens (Human))
Piramal Life Sciences

Curated by ChEMBL
LigandPNGBDBM50298008(3-(3-(3-(3-fluoro-4-methoxyphenyl)-4,5-dihydroisox...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of dopachrome tautomerase activity of MIF in human THP1 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z0387WPubMed
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